Peptic Ulcer Disease

List 2 common sites of peptic ulcer disease

1) Duodenum

2) Stomach

What is the commonest site of peptic ulcer disease?

Duodenum

Which bacteria increases the risk of peptic ulcer disease?

Helicobacter pylori

What effect does food often have on the pain of a gastric ulcer?

Worsens

What effect does food often have on the pain of a duodenal ulcer?

Improves

Which organism does the CLO test investigate for?

Helicobacter pylori

What is the investigation of choice to diagnose peptic ulcer disease?

Upper GI endoscopy

What is the main medical treatment for peptic ulcer disease?

Proton pump inhibitor (PPI)

What is the commonest cause of an acute upper gastrointestinal haemorrhage?

Peptic ulcer disease

Bleeding from which region of the gastrointestinal tract will cause melaena?

Proximal to and including the caecum

Which region of the gastrointestinal tract is typically affected by a Mallory-Weiss tear?

Gastro-oesophageal junction

List 3 non-invasive tests for Helicobacter pylori

1) Serology

2) Stool antigen

3) 13C breath test

Which is the most accurate non-invasive test for Helicobacter pylori?

13C breath test

List 3 invasive tests for Helicobacter pylori

1) CLO test

2) Culture

3) Histology

How long should PPI treatment be stopped for before testing for Helicobacter pylori?

More than 2 weeks off PPI treatment - except for serology